Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

Kamar-Sulu N. Atretkhanya, Ilgiz A. Mufazalova, Josefine Dunstd, Anna Kuchmiy, Violetta S. Gogoleva, David Andruszewski, Marina S. Drutskaya, Denise L. Faustman, Marius Schwabenland, Marco Prinz, Andrey A. Kruglov, Ari Waisman, and Sergei A. Nedospasov

1807499115 PNAS 2018

Bridging the gap between vaccination with Bacille Calmette-Gue ́rin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis

Giovanni Ristori, Denise Faustman, Giuseppe Matarese, Silvia Romano and Marco Salvetti

55:89–96 Current Opinion in Immunology 2018

Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome

H Torrey, M Khodadoust, L Tran, D Baum, A Defusco, Y H Kim, D L Faustman1
BCG Nature Leukemia s 2018 October 24

Long-term Reduction in Hyperglycemia in Advanced Type 1 Diabetes: The Value of Induced Aerobic Glycolysis with BCG Vaccinations

Willem M. Kühtreiber, Lisa Tran, Taesoo Kim, Michael Dybala, Brian Nguyen, Sara Plager, Daniel Huang, Sophie Janes, Audrey Defusco, Danielle Baum, Hui Zheng & Denise L. Faustman
BCG npj Vaccines 2018 June 21

Structural Principles of Tumor Necrosis Factor Superfamily Signaling

Vanamee ÉS, Faustman DL. Sci Signal. 2018 Jan 2;11(511). pii: eaao4910. doi: 10.1126/scisignal.aao4910. Review.

TNFR2: A Novel Target for Cancer Immunotherapy

Vanamee ÉS, Faustman DL. Trends Mol Med. 2017 Nov;23(11):1037-1046. doi: 10.1016/j.molmed.2017.09.007. Epub 2017 Oct 12. Review.
PMID: 29032004

TNF, TNF Inducers, and TNFR2 Agonists: A New Path to Type 1 Diabetes Treatment

Faustman DL. Diabetes Metab Res Rev. 2018 Jan;34(1). doi: 10.1002/dmrr.2941. Epub 2017 Sep 29. Review.
PMID: 28843039

Targeting TNFR2 with Antagonistic Antibodies Inhibits Proliferation of Ovarian Cancer Cells and Tumor-associated Tregs

Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL. Sci Signal.2017 Jan 17;10(462). pii: eaaf8608. doi: 10.1126/scisignal.aaf8608.
PMID: 28096513

Treg Activation Defect In Type 1 Diabetes: Correction With TNFR2 Agonism

Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL.
Clin Transl Immunology. 2016 Jan 8;5(1):e56. doi: 10.1038/cti.2015.43. eCollection 2016 Jan.
PMID: 26900470 Free PMC Article

Strategic Internal Covalent Cross-linking of TNF Produces A Stable TNF Trimer with Improved TNFR2 Signaling

Ban L, Kuhtreiber W, Butterworth J, Okubo Y, Vanamee ÉS, Faustman DL.
Mol Cell Ther. 2015 Aug 12;3:7. doi: 10.1186/s40591-015-0044-4. eCollection 2015.

Low Levels of C-peptide Have Clinical Significance for Established Type 1 Diabetes

Kuhtreiber WM, Washer SL, Hsu E, Zhao M, Reinhold P 3rd, Burger D, Zheng H, Faustman DL.
Diabet Med. 2015 Oct;32(10):1346-53. doi: 10.1111/dme.12850. Epub 2015 Aug 16.
PMID: 26172028 Free PMC Article

Removal of Donor Human Leukocyte Antigen Class I Proteins With Papain: Translation for Possible Whole Organ Practices

Mera T, Faustman DL.
Transplantation. 2015 Apr;99(4):724-30. doi: 10.1097/TP.0000000000000436.
PMID: 25340603

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

Faustman DL, Davis M.
Front Immunol. 2013 Dec 23;4:478. doi: 10.3389/fimmu.2013.00478.
PMID: 24391650 Free PMC Article

Homogeneous Expansion Of Human T-regulatory Cells Via Tumor Necrosis Factor Receptor 2

Okubo Y, Mera T, Wang L, Faustman DL.
Sci Rep. 2013 Nov 6;3:3153. doi: 10.1038/srep03153.
PMID: 24193319 Free PMC Article

Why Were We Wrong For So Long? The Pancreas Of Type 1 Diabetic Patients Commonly Functions for Decades

Faustman DL. Diabetologia. 2014 Jan;57(1):1-3. doi: 10.1007/s00125-013-3104-9. Epub 2013 Nov 5.
PMID: 24190583

Proof-of-concept, Randomized, Controlled Clinical Trial Of Bacillus-Calmette-Guerin For Treatment Of Long-term Type 1 Diabetes

Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.
PLoS One. 2012;7(8):e41756. doi: 10.1371/journal.pone.0041756. Epub 2012 Aug 8.
PMID: 22905105 Free PMC Article

Persistence of Prolonged C-peptide Production In Type 1 Diabetes As Measured With An Ultrasensitive C-peptide Assay

Wang L, Lovejoy NF, Faustman DL.
Diabetes Care. 2012 Mar;35(3):465-70. doi: 10.2337/dc11-1236.
PMID: 22355018 Free PMC Article

Novel Automated Blood Separations Validate Whole Cell Biomarkers

Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL.
PLoS One. 2011;6(7):e22430. doi: 10.1371/journal.pone.0022430. Epub 2011 Jul 22.
PMID: 21799852 Free PMC Article

Stem Cells In The Spleen: Therapeutic Potential For Sjogren’s Syndrome, Type I Diabetes, And Other Disorders

Faustman DL, Davis M.
Int J Biochem Cell Biol. 2010 Oct;42(10):1576-9. doi: 10.1016/j.biocel.2010.06.012. Epub 2010 Jun 18. Review.
PMID: 20601088 Free PMC Article

The Primacy Of CD8 T Lymphocytes In Type 1 Diabetes And Implications For Therapies

Faustman DL, Davis M.
J Mol Med (Berl). 2009 Dec;87(12):1173-8. doi: 10.1007/s00109-009-0516-6. Epub 2009 Aug 21. Review.
PMID: 19693476

Selective Death Of Autoreactive T Cells In Human Diabetes By TNF Or TNF Receptor 2 Agonism

Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL.
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13644-9. doi: 10.1073/pnas.0803429105. Epub 2008 Aug 28.
PMID: 18755894 Free PMC Article

Fetal Hox11 Expression Patterns Predict Defective Target Organs: A Novel Link Between Developmental Biology And Autoimmunity

Lonyai A, Kodama S, Burger D, Faustman DL.
Immunol Cell Biol. 2008 May-Jun;86(4):301-9. doi: 10.1038/icb.2008.6. Epub 2008 Feb 26.
PMID: 18301381 Free PMC Article

The Promise of Hox11+ Stem Cells Of The Spleen For Treating Autoimmune Diseases

Lonyai A, Kodama S, Burger D, Davis M, Faustman DL.
Horm Metab Res. 2008 Feb;40(2):137-46. doi: 10.1055/s-2007-1022560. Review.
PMID: 18283632

Comment On Papers By Chong et al., Nishio et al., and Suri et al. On Diabetes Reversal In NOD Mice

Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E.
Science. 2006 Nov 24;314(5803):1243; author reply 1243.
PMID: 17124308