Publications
Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity
Kamar-Sulu N. Atretkhanya, Ilgiz A. Mufazalova, Josefine Dunstd, Anna Kuchmiy, Violetta S. Gogoleva, David Andruszewski, Marina S. Drutskaya, Denise L. Faustman, Marius Schwabenland, Marco Prinz, Andrey A. Kruglov, Ari Waisman, and Sergei A. Nedospasov
1807499115 PNAS 2018
Bridging the gap between vaccination with Bacille Calmette-Gue ́rin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis
Giovanni Ristori, Denise Faustman, Giuseppe Matarese, Silvia Romano and Marco Salvetti
55:89–96 Current Opinion in Immunology 2018
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome
H Torrey, M Khodadoust, L Tran, D Baum, A Defusco, Y H Kim, D L Faustman1
BCG Nature Leukemia s 2018 October 24
Long-term Reduction in Hyperglycemia in Advanced Type 1 Diabetes: The Value of Induced Aerobic Glycolysis with BCG Vaccinations
Willem M. Kühtreiber, Lisa Tran, Taesoo Kim, Michael Dybala, Brian Nguyen, Sara Plager, Daniel Huang, Sophie Janes, Audrey Defusco, Danielle Baum, Hui Zheng & Denise L. Faustman
BCG npj Vaccines 2018 June 21
Structural Principles of Tumor Necrosis Factor Superfamily Signaling
Vanamee ÉS, Faustman DL. Sci Signal. 2018 Jan 2;11(511). pii: eaao4910. doi: 10.1126/scisignal.aao4910. Review.
PMID:29295955
TNFR2: A Novel Target for Cancer Immunotherapy
Vanamee ÉS, Faustman DL. Trends Mol Med. 2017 Nov;23(11):1037-1046. doi: 10.1016/j.molmed.2017.09.007. Epub 2017 Oct 12. Review.
PMID: 29032004
TNF, TNF Inducers, and TNFR2 Agonists: A New Path to Type 1 Diabetes Treatment
Faustman DL. Diabetes Metab Res Rev. 2018 Jan;34(1). doi: 10.1002/dmrr.2941. Epub 2017 Sep 29. Review.
PMID: 28843039
Targeting TNFR2 with Antagonistic Antibodies Inhibits Proliferation of Ovarian Cancer Cells and Tumor-associated Tregs
Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL. Sci Signal.2017 Jan 17;10(462). pii: eaaf8608. doi: 10.1126/scisignal.aaf8608.
PMID: 28096513
Treg Activation Defect In Type 1 Diabetes: Correction With TNFR2 Agonism
Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL.
Clin Transl Immunology. 2016 Jan 8;5(1):e56. doi: 10.1038/cti.2015.43. eCollection 2016 Jan.
PMID: 26900470 Free PMC Article
Strategic Internal Covalent Cross-linking of TNF Produces A Stable TNF Trimer with Improved TNFR2 Signaling
Ban L, Kuhtreiber W, Butterworth J, Okubo Y, Vanamee ÉS, Faustman DL.
Mol Cell Ther. 2015 Aug 12;3:7. doi: 10.1186/s40591-015-0044-4. eCollection 2015.
Low Levels of C-peptide Have Clinical Significance for Established Type 1 Diabetes
Kuhtreiber WM, Washer SL, Hsu E, Zhao M, Reinhold P 3rd, Burger D, Zheng H, Faustman DL.
Diabet Med. 2015 Oct;32(10):1346-53. doi: 10.1111/dme.12850. Epub 2015 Aug 16.
PMID: 26172028 Free PMC Article
Removal of Donor Human Leukocyte Antigen Class I Proteins With Papain: Translation for Possible Whole Organ Practices
Mera T, Faustman DL.
Transplantation. 2015 Apr;99(4):724-30. doi: 10.1097/TP.0000000000000436.
PMID: 25340603
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine
Faustman DL, Davis M.
Front Immunol. 2013 Dec 23;4:478. doi: 10.3389/fimmu.2013.00478.
PMID: 24391650 Free PMC Article
Homogeneous Expansion Of Human T-regulatory Cells Via Tumor Necrosis Factor Receptor 2
Okubo Y, Mera T, Wang L, Faustman DL.
Sci Rep. 2013 Nov 6;3:3153. doi: 10.1038/srep03153.
PMID: 24193319 Free PMC Article
Why Were We Wrong For So Long? The Pancreas Of Type 1 Diabetic Patients Commonly Functions for Decades
Faustman DL. Diabetologia. 2014 Jan;57(1):1-3. doi: 10.1007/s00125-013-3104-9. Epub 2013 Nov 5.
PMID: 24190583
Proof-of-concept, Randomized, Controlled Clinical Trial Of Bacillus-Calmette-Guerin For Treatment Of Long-term Type 1 Diabetes
Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.
PLoS One. 2012;7(8):e41756. doi: 10.1371/journal.pone.0041756. Epub 2012 Aug 8.
PMID: 22905105 Free PMC Article
Persistence of Prolonged C-peptide Production In Type 1 Diabetes As Measured With An Ultrasensitive C-peptide Assay
Wang L, Lovejoy NF, Faustman DL.
Diabetes Care. 2012 Mar;35(3):465-70. doi: 10.2337/dc11-1236.
PMID: 22355018 Free PMC Article
Novel Automated Blood Separations Validate Whole Cell Biomarkers
Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL.
PLoS One. 2011;6(7):e22430. doi: 10.1371/journal.pone.0022430. Epub 2011 Jul 22.
PMID: 21799852 Free PMC Article
Stem Cells In The Spleen: Therapeutic Potential For Sjogren’s Syndrome, Type I Diabetes, And Other Disorders
Faustman DL, Davis M.
Int J Biochem Cell Biol. 2010 Oct;42(10):1576-9. doi: 10.1016/j.biocel.2010.06.012. Epub 2010 Jun 18. Review.
PMID: 20601088 Free PMC Article
The Primacy Of CD8 T Lymphocytes In Type 1 Diabetes And Implications For Therapies
Faustman DL, Davis M.
J Mol Med (Berl). 2009 Dec;87(12):1173-8. doi: 10.1007/s00109-009-0516-6. Epub 2009 Aug 21. Review.
PMID: 19693476
Selective Death Of Autoreactive T Cells In Human Diabetes By TNF Or TNF Receptor 2 Agonism
Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL.
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13644-9. doi: 10.1073/pnas.0803429105. Epub 2008 Aug 28.
PMID: 18755894 Free PMC Article
Fetal Hox11 Expression Patterns Predict Defective Target Organs: A Novel Link Between Developmental Biology And Autoimmunity
Lonyai A, Kodama S, Burger D, Faustman DL.
Immunol Cell Biol. 2008 May-Jun;86(4):301-9. doi: 10.1038/icb.2008.6. Epub 2008 Feb 26.
PMID: 18301381 Free PMC Article
The Promise of Hox11+ Stem Cells Of The Spleen For Treating Autoimmune Diseases
Lonyai A, Kodama S, Burger D, Davis M, Faustman DL.
Horm Metab Res. 2008 Feb;40(2):137-46. doi: 10.1055/s-2007-1022560. Review.
PMID: 18283632
Comment On Papers By Chong et al., Nishio et al., and Suri et al. On Diabetes Reversal In NOD Mice
Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E.
Science. 2006 Nov 24;314(5803):1243; author reply 1243.
PMID: 17124308